Progesterone - Its Uses and Effects

Source Naturals Progesterone Cream

Progesterone has been used as therapy for PMS syndrome and for women with infertility or frequent pregnancy loss.
Is it better to take progesterone as a pill, a shot, a vaginal suppository or a cream?

All of the above forms of progesterone and progestogens have been used.

Absorption and duration of action will vary by the form of progesterone used:

Pills - peak absorption is about 1-4 hours and is cleared by 24 hours. Taking the pills with food enhances absorption.

Shots - usually given in the form of progesterone in oil, doses peak at about 12 hours after administration and take at least 48 hours or more to clear. There are depot forms of medroxyprogesterone acetate (Depo-Provera®) that last at least 12 weeks which gives it its contraceptive effect.

Vaginal suppositories, cream - absorbed to peak in 4 hours and cleared by 24 hours. Sometimes mixed in cocoa butter or propylene glycol as the carrying agent. A cream is also commercially available (Crinone®).

Skin creams - creams tend not to absorb through the skin very well but alcohol-based gels are effective with a once a day application. A 10% alcohol and propylene glycol base also seems to be quite effective and clears by 24 hours.

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Category: bio-identical hormones, Hormones, progesterone