Prednisone and Aspirin Therapy

Photo credit: baby aspirin, by looseid

Habitual abortions - don't you just love that term??? As if women just have a bad habit of aborting their babies!? But it's an interesting study, and just might help those who are experiencing recurrent loss.

Note: these women received 20mg/day of prednisone for up to 12 weeks, plus 100mg/day of aspirin until the end of their seventh month.

Habitual abortions in 678 healthy patients: investigation and prevention
The objective of this study of patients with habitual abortion (HA), was to determine their autoimmune profile and to try to prevent new abortions using low-dose aspirin for 7 months with prednisone in the first trimester only, or with low-dose aspirin alone.

Habitual abortion (HA) may be associated with anatomic, genetic, or hormonal abnormalities, or autoimmune diseases, such as systemic lupus erythematosus or antiphospholipid syndrome.

Prednisone and aspirin treatment have the same success rate in both autoantibody-negative and autoantibody-positive women. The results presented here confirm those of a recent study (Geva et al., 1998).

In autoantibody-negative women, the rate of live births in the group of women treated with prednisone in the first trimester and aspirin until the end of the seventh month was significantly increased compared with women treated with aspirin alone: 90.7% of women (146 out of 161) treated with prednisone and aspirin had live births compared with 74.5% of women (47 out of 63) treated with aspirin alone.

In autoantibody-positive women (45 out of 53) the rate of live births was 84.9%; there was no significant difference in the rate of live births between autoantibody-negative and autoantibody-positive women.

As observed in women with aCL greater than 30 uGPL, prednisone plus aspirin appeared to be less successful than in a group of aCL 30 uGPL, it is suggested that in the former group, after prednisone is stopped, heparin should be considered if the aCL titre rises. With lupus anticoagulant, heparin should be the treatment of choice as heparin is superior to low-dose aspirin (Kutteh et al., 1996; Di Simone et al., 1997).

Read the full article

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Category: aspirin, Miscarriage, prednisone, pregnancy loss