Photo credit: Baby and Grandma captured in a cuddle, by Loserlady Sharing articles I find, discussing options you might consider and suggesting what might help. Each person is different, what works for one might really mess up another. So what you do with this info is entirely up to you! ...
Photo credit: Shaddy with the godmother at the park, by Eleanore Fern Pagaduan In 2015, there were 224,938 live births in the United States to women ages 40 through 54... 754 of those live births to women 50-54... In 2014, there were only 783 live births to women over 43, using donor eggs...
Photo credit: Baby smiling, bebe riendo, by Juan Pablo Oitana Personally I find the statistics we get about Down's Syndrome somewhat confusing. So I translated them into percentages. I think it is all too easy to think of 1-80 as one in 80%, but it is not. 1-80 translates to 1.25 % for DS, or
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From: Journal of Clinical Investigation
Public release date: 14-Sep-2006
Complications in pregnancy can arise because of both fetal deficiencies and maternal deficiencies. Previous studies in the Caron laboratory have shown that mouse embryos lacking both copies of the gene encoding a protein known as adrenomedullin (AM) die at embryonic day 14.5 (E14.5).
But now, Kathleen Caron and colleagues at the University of North Carolina at Chapel Hill show that female mice expressing reduced levels of the gene encoding AM have severely decreased fertility. It is therefore possible that modest alterations in human expression of the gene encoding AM might have implications for fertility.
In the study, which appears online on September 14 in advance of publication in the October print issue of the The Journal of Clinical Investigation, it was shown that female mice with only one copy of the gene encoding AM (AM+/- mice) crossed with wild-type male mice have smaller litters than wild-type female mice crossed with either AM+/- or wild-type male mice.
Reduced litter size was associated with fetal-growth restriction and embryo loss at E9.5–E12.5, which is when the placenta develops. Indeed, the placentas of growth-restricted embryos were closely spaced and showed morphologic and histologic defects.
This study shows that in female mice a reduction in the level of AM severely decreases their fertility by affecting implantation and placental development, and suggests that in humans a small decrease in AM expression could negatively impact a woman's fertility.
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TITLE: Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice
AUTHOR CONTACT: Kathleen M. Caron The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Phone: (919) 966-5215; Fax: (919) 966-5230; E-mail: Kathleen_caron@med.unc.edu .
View the PDF of this article at: https://www.the-jci.org/article.php?id=28462
Posted from "EurekAlert! , a service of AAAS"
Category: Genes, Miscarriage, research
About Catherine: I am mom to three grown sons, two grandchildren and two rescue dogs. After years of raising my boys as a single mom, I remarried a wonderful man who had never had a child of his own. Unexpectedly, I found myself pregnant at 49!
Sadly we lost that precious baby at 8 weeks, and decided to try again. Five more losses, turned down for donor egg, foster care and adoption due to my age and losses - we have accepted that there will be no more babies in our house.
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